With increased life expectancy and the “baby boomers” aging peak, the prevalence of cognitive impairments (CI) including major cognitive impairment (thereafter called “dementia”) will double in the next two decades, leading to a major health, social and economic burden. Most cases of CI will be related to pure and mixed forms of Alzheimer and vascular cognitive diseases. While the impact of vascular and metabolic risk factors on CI is well recognized, the knowledge of the pathological mechanisms, the predictive outcomes and the best therapies for vascular cognitive disorders are yet to be better defined.
The FHU VasCog project has focused its activities for research and for care management on three main topics:
- Stroke-associated cognitive disorders (CDs);
- Diabetes-associated CDs;
- Silent Brain lesion-associated CDs (small vessels disease as cerebral amyloid angiopathy and arteriolosclerosis due to vascular risk factors))